HIV-1 Rev 反应元件：一种指导同源寡聚核糖核蛋白复合物协同组装的 RNA 支架。
The HIV-1 Rev response element: an RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex.
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
出版信息
RNA Biol. 2012 Jan;9(1):6-11. doi: 10.4161/rna.9.1.18178. Epub 2012 Jan 1.
The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions.
HIV-1 Rev 反应元件（RRE）是一个约 350 个核苷酸的、高度结构化的顺式作用 RNA 元件，对病毒复制至关重要。它位于病毒基因组的 env 编码区，在不同的 HIV-1 分离株中高度保守。它存在于所有部分剪接和未剪接的病毒 mRNA 转录本中，作为一个 RNA 框架，其上组装有多个病毒蛋白 Rev 分子。Rev-RRE 寡聚复合物介导这些信息从核内输出到细胞质，在细胞质中它们被翻译产生必需的病毒蛋白和/或包装为新病毒粒子的基因组。
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