Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, 650500 Yunnan, China.
Arch Gynecol Obstet. 2012 Jun;285(6):1657-61. doi: 10.1007/s00404-012-2226-5. Epub 2012 Jan 19.
p53 tumour suppressor gene Arg72Pro polymorphism has been associated with endometriosis. However, the current available data were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and endometriosis.
Electronic screening of PubMed library was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association.
Six published studies, including 749 endometriosis and 857 controls were identified. The overall results suggested that the variant genotypes were not associated with the endometriosis risk (Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 1.552, 95% CI 0.916-2.632, p = 0.103). In the stratified analysis, individuals carried the Pro allele in a dominant model had increased risk of endometriosis (OR = 2.595, 95% CI 1.005-6.702, p = 0.049) in Asian subjects. The symmetric funnel plot, the Egger's test (p = 0.602), and the Begg's test (p = 0.167) were all suggestive of the lack of publication bias. However, the association was not significant between this polymorphism and endometriosis in Caucasian (OR = 1.005, 95% CI 0.755-1.337, p = 0.972).
This meta-analysis suggests that p53 codon 72 Pro/Pro + Arg/Pro genotypes are associated with increased risk of endometriosis in Asian. To validate the association between p53 codon 72 polymorphism and endometriosis, further studies with larger participants worldwide are needed.
p53 肿瘤抑制基因 Arg72Pro 多态性与子宫内膜异位症有关。然而，目前的可用数据不一致。我们进行了这项荟萃分析，以评估 p53 Arg72Pro 多态性与子宫内膜异位症之间的关系。
通过电子方式在 PubMed 文库中进行筛选，以选择研究。选择包含 Arg72Pro 可用基因型频率的研究，并使用合并的优势比 (OR) 和 95%置信区间 (CI) 来评估相关性。
确定了六项已发表的研究，包括 749 例子宫内膜异位症和 857 例对照。总体结果表明，变体基因型与子宫内膜异位症风险无关（Pro/Pro+Arg/Pro 与 Arg/Arg：OR=1.552，95%CI0.916-2.632，p=0.103）。在分层分析中，在亚洲人群中，个体以显性模式携带 Pro 等位基因时，子宫内膜异位症的风险增加（OR=2.595，95%CI1.005-6.702，p=0.049）。对称漏斗图、Egger 检验（p=0.602）和 Begg 检验（p=0.167）均表明不存在发表偏倚。然而，这种多态性与白种人子宫内膜异位症之间没有显著关联（OR=1.005，95%CI0.755-1.337，p=0.972）。
这项荟萃分析表明，p53 密码子 72 Pro/Pro+Arg/Pro 基因型与亚洲人群子宫内膜异位症的风险增加相关。为了验证 p53 密码子 72 多态性与子宫内膜异位症之间的关联，需要在全球范围内进行更多具有更大参与者的研究。
