Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan, China.
Cancer Epidemiol. 2012 Jun;36(3):e153-7. doi: 10.1016/j.canep.2011.12.010. Epub 2012 Jan 23.
It has been suggested that the p53 tumor suppressor gene Arg72Pro polymorphism is associated with endometrial cancer. However, results have been inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and endometrial cancer.
An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assessed by pooled odds ratios (ORs) with 95% confidence intervals (CIs).
Nine published studies, including 829 endometrial cancer cases and 1387 controls, were identified. The overall results suggested that the variant genotypes were not associated with the endometrial cancer risk in all genetic models (additive model: OR 1.027, 95% CI 0.893-1.18, P=0.71; recessive model: OR 1.099, 95% CI 0.802-1.507, P=0.556; dominant model: OR 1.013, 95% CI 0.842-1.219 P=0.89). Similarly, the results were negative in subgroup analyses for ethnicity (Caucasian, Asian).
This meta-analysis suggests that p53 codon 72 polymorphism is not associated with increased risk of endometrial cancer, especially in Caucasians and Asians. To validate the association between this polymorphism and endometrial cancer, further studies with larger numbers of participants worldwide are needed.
有研究表明，p53 肿瘤抑制基因 Arg72Pro 多态性与子宫内膜癌有关。然而，结果并不一致。我们进行了这项荟萃分析，以评估 p53 Arg72Pro 多态性与子宫内膜癌之间的关系。
通过电子检索 PubMed 来选择研究。选择包含 Arg72Pro 基因型频率的研究，并通过汇总优势比（ORs）及其 95%置信区间（CIs）来评估相关性。
共纳入 9 项已发表的研究，包括 829 例子宫内膜癌病例和 1387 例对照。总体结果表明，在所有遗传模型中，变体基因型与子宫内膜癌风险无关（相加模型：OR 1.027，95%CI 0.893-1.18，P=0.71；隐性模型：OR 1.099，95%CI 0.802-1.507，P=0.556；显性模型：OR 1.013，95%CI 0.842-1.219，P=0.89）。同样，在种族亚组分析（白种人、亚洲人）中结果也是阴性的。
本荟萃分析表明，p53 密码子 72 多态性与子宫内膜癌风险增加无关，特别是在白种人和亚洲人群中。为了验证这种多态性与子宫内膜癌之间的关联，需要在全球范围内进行更多参与者的研究。
