营养过剩与心肾综合征：利用啮齿动物模型研究机制
Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms.
作者信息
Whaley-Connell Adam, Pulakat Lakshmi, DeMarco Vincent G, Hayden Melvin R, Habibi Javad, Henriksen Erik J, Sowers James R
出版信息
Cardiorenal Med. 2011;1(1):23-30. doi: 10.1159/000322827. Epub 2011 Jan 17.
Abstract
Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.
摘要
肥胖已达到流行程度，对医疗保健和经济产生了深远影响。以碳水化合物和脂肪摄入过多为特征的营养过剩，与包括心脏和肾脏在内的多个组织的终末器官损伤有关。此外，营养过剩是与心血管和肾脏疾病相关的发病和死亡的最重要的可改变和可预防的原因之一。胰岛素抵抗、代偿性高胰岛素血症以及包括肾素-血管紧张素-醛固酮系统活性增强、炎症和氧化应激在内的相关机制，已被认为与肥胖相关的心肾损伤有关。在本综述中，在营养过剩和肥胖的啮齿动物模型——Zucker肥胖大鼠中，评估了营养过剩对心脏和肾脏疾病的影响。
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