三结构域家族成员在介导 HIV-1 感染易感性中的作用。
The role of tripartite motif family members in mediating susceptibility to HIV-1 infection.
机构信息
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
出版信息
Curr Opin HIV AIDS. 2012 Mar;7(2):180-6. doi: 10.1097/COH.0b013e32835048e1.
PURPOSE OF REVIEW
This review highlights new roles of the large family of tripartite motif (TRIM) proteins in antiviral defense.
RECENT FINDINGS
Recent research explores the participation of several TRIM family members in regulating the innate immune response. A large number of TRIM genes are upregulated upon treatment by interferon and are directly involved in signaling (TRIM5, 13, 16, 20, 21, 22, 23, 25, 27, 30, 32 and 38). Notably, TRIM5α has been identified as a 'pattern recognition receptor' triggering a cascade of signals upon viral recognition, and contributing to the establishment of the antiviral state.
SUMMARY
The identification of new roles for TRIM5α and other family members contributes to an emerging paradigm of host antiretroviral factors as mediators of the innate immune response and of the antiviral state. This leads both to direct therapeutic applications, such as gene therapy, and to the possibility of immune modulation.
目的综述
本文重点介绍了三联基序蛋白（TRIM）大家族在抗病毒防御中的新作用。
最近的发现
最近的研究探讨了几个 TRIM 家族成员在调节先天免疫反应中的参与。干扰素处理后，大量的 TRIM 基因上调，并直接参与信号转导（TRIM5、13、16、20、21、22、23、25、27、30、32 和 38）。值得注意的是，TRIM5α 已被鉴定为“模式识别受体”，在病毒识别后触发一连串信号，有助于建立抗病毒状态。
总结
TRIM5α 和其他家族成员新作用的鉴定有助于形成一个新的宿主抗逆转录病毒因子范式，作为先天免疫反应和抗病毒状态的介质。这既导致了直接的治疗应用，如基因治疗，也为免疫调节提供了可能。
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