The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
Nature. 2012 Jan 18;481(7381):287-94. doi: 10.1038/nature10760.
Genomic instability is one of the most pervasive characteristics of tumour cells and is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells. Although these processes drive genomic instability and ultimately the disease process, they also provide therapeutic opportunities. A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease.
基因组不稳定性是肿瘤细胞最普遍的特征之一，可能是 DNA 损伤、肿瘤特异性 DNA 修复缺陷以及在受损 DNA 传递给子细胞之前无法停止或停滞细胞周期的综合作用。尽管这些过程驱动了基因组不稳定性，并最终导致了疾病进程，但它们也提供了治疗机会。更好地了解细胞对 DNA 损伤的反应不仅将丰富我们对癌症发展的认识，还有助于完善疾病的分类和治疗。
