针对癌症治疗的DNA损伤反应的靶向策略。
Strategies for targeting the DNA damage response for cancer therapeutics.
作者信息
Zhang Dan, Wang Hai-Bo, Brinkman Kathryn L, Han Su-Xia, Xu Bo
出版信息
Chin J Cancer. 2012 Aug;31(8):359-63. doi: 10.5732/cjc.012.10087. Epub 2012 Jun 14.
Abstract
The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
摘要
DNA损伤反应对于细胞维持基因组稳定性和生存至关重要。在本综述中，我们讨论了针对DNA损伤反应关键元件进行放射增敏和化学增敏的方法。此外，我们还讨论了针对癌细胞中DNA损伤反应和DNA修复缺陷以实现合成致死的策略。
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