胰岛素预处理（印记）对Chang细胞系和CHO细胞系中胰岛素诱导的有丝分裂活性的影响。
Impact of pretreatment (imprinting) with insulin on insulin-induced mitotic activity in Chang and CHO cell lines.
作者信息
Csaba G, Török O
机构信息
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
出版信息
Cytobios. 1990;62(250-251):149-52.
PMID:2225935
Abstract
Primary interaction with insulin increased the mitotic activity of Chang liver and Chinese hamster ovary (CHO) cells. Re-exposure to insulin accounted for a significant increase of mitoses over the control, but for a considerable decrease thereof relative to the effect of primary exposure. The hormone had a more pronounced effect on its direct target cells (Chang liver cells) than on the CHO cells.
摘要
胰岛素的初次作用增加了张氏肝细胞和中国仓鼠卵巢（CHO）细胞的有丝分裂活性。再次暴露于胰岛素导致有丝分裂相对于对照组显著增加，但相对于初次暴露的效果则大幅下降。该激素对其直接靶细胞（张氏肝细胞）的作用比对CHO细胞更为显著。
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