Lilienfeld D E, Chan E, Ehland J, Godbold J H, Landrigan P J, Marsh G
Division of Environmental and Occupational Medicine, Mount Sinai School of Medicine, New York 10028.
Chest. 1990 Nov;98(5):1067-72. doi: 10.1378/chest.98.5.1067.
To examine the effect of advances in the prevention of and therapy for PE, we reviewed mortality for PE in the United States from 1962 to 1984. Age-adjusted PE mortality increased by 67 to 100 percent between 1962 and 1974 for white and non-white men and women. From 1975 to 1984, these rates declined by 20 to 28 percent. Non-white PE mortality was greater than white PE mortality; men had a greater risk of PE death than women. Age-specific patterns (more than 40 years of age) of PE mortality followed those of the age-adjusted death rates, with increases noted in all groups between 1962 and 1974 and declines during the 1975-1984 period. These patterns might reflect improved ascertainment of cases and better prevention of disease. The magnitude of the rates suggests that the list of indications for prophylactic anticoagulation should be re-examined for possible expansion.
为研究肺栓塞预防和治疗进展的影响，我们回顾了1962年至1984年美国肺栓塞的死亡率。1962年至1974年间，白人和非白人男性及女性经年龄调整后的肺栓塞死亡率上升了67%至100%。1975年至1984年，这些比率下降了20%至28%。非白人肺栓塞死亡率高于白人肺栓塞死亡率；男性肺栓塞死亡风险高于女性。肺栓塞死亡率的年龄特异性模式（40岁以上）与年龄调整后的死亡率模式一致，1962年至1974年间所有组均有所上升，1975 - 1984年期间有所下降。这些模式可能反映了病例确诊的改善和疾病预防的加强。这些比率的幅度表明，应重新审视预防性抗凝的适应证清单，看是否有可能扩大。
