Department of Chronic Diseases and Injuries, French Institute for Public Health Surveillance, Saint Maurice, France.
Department of Chronic Diseases and Injuries, French Institute for Public Health Surveillance, Saint Maurice, France.
Thromb Res. 2015 Feb;135(2):334-8. doi: 10.1016/j.thromres.2014.12.002. Epub 2014 Dec 5.
Pulmonary Embolism (PE) is a potentially fatal complication of venous thrombosis. Recent and comprehensive estimates of PE incidence and mortality are scarce. Moreover, while contemporary mortality trends of PE would enable the evaluation of prevention and quality of care, such data are lacking. The aim of this study was to provide nationwide estimations of PE mortality and time trends in France between 2000 and 2010.
Mortality data were obtained from the French Epidemiology Center on medical causes of death. Mortality rates were calculated with PE as an underlying or one of multiple causes of death. The annual percentage changes were assessed using a Poisson regression model. Age-standardized PE mortality rates were also assessed.
In 2010, the overall age-adjusted PE mortality rate was 21.0 per 100000. This rate was 30% higher in men than in women and decreased by 3% per year between 2000 and 2010. Over this period, PE mortality declined in men and women over 55 years but only slightly decreased in patients younger than 55. Cancer, obesity, osteopathies and complications of surgery were often coded as the underlying causes of death when PE was an associated cause of death recorded on certificate.
This study is the first to provide a contemporary and exhaustive nationwide estimation of PE mortality and time trends in France. The observed decrease in PE mortality between 2000 and 2010 is encouraging, but further efforts in prevention are needed to ensure that this reduction is widespread in all age groups.
肺栓塞（PE）是静脉血栓形成的一种潜在致命并发症。目前缺乏对 PE 发病率和死亡率的最新和全面估计。此外，虽然当代 PE 死亡率趋势可以评估预防和护理质量，但缺乏此类数据。本研究旨在提供法国 2000 年至 2010 年期间全国范围内的 PE 死亡率和时间趋势估计。
死亡率数据来自法国流行病学中心的死因医学数据。死亡率计算以 PE 作为根本或多种死因之一。使用泊松回归模型评估年百分比变化。还评估了年龄标准化的 PE 死亡率。
2010 年，总体年龄调整后的 PE 死亡率为 21.0/100000。男性的这一比率比女性高 30%，2000 年至 2010 年间每年下降 3%。在此期间，55 岁以上男性和女性的 PE 死亡率下降，但 55 岁以下患者的死亡率略有下降。癌症、肥胖症、整骨疗法和手术并发症通常被编码为 PE 作为相关死因记录在死亡证明上时的根本死因。
本研究首次提供了法国当代和全面的 PE 死亡率和时间趋势的估计。2000 年至 2010 年间观察到的 PE 死亡率下降令人鼓舞，但仍需进一步努力预防，以确保这种减少在所有年龄组中广泛发生。
