Suen J S, Forse M S, Hyland R H, Chan C K
Division of Respiratory and Critical Care Medicine, Wellesley Hospital, University of Toronto, Canada.
Chest. 1990 Nov;98(5):1300-2. doi: 10.1378/chest.98.5.1300.
In a retrospective review of six patients with malignancy preceding sarcoidosis, we found four cases of malignant lymphoproliferative disease (LD) and one case each of ovarian cancer and breast cancer. The median interval from onset or relapse of malignancy to sarcoidosis was nine months. Of the four patients with LD, sarcoidosis appeared within six months of termination of chemotherapy for three of the patients and 15 months after allogeneic bone marrow transplantation for the fourth patient. At the time of diagnosis of sarcoidosis, there was no clinical or pathologic evidence of malignancy in the chest. We conclude that in contradistinction to the previously described syndrome of sarcoidosis preceding LD, there exists a syndrome of sarcoidosis following malignancy with or without chemotherapy.
在一项对6例在结节病之前患有恶性肿瘤患者的回顾性研究中，我们发现4例恶性淋巴增殖性疾病（LD），1例卵巢癌和1例乳腺癌。从恶性肿瘤发病或复发到结节病的中位间隔时间为9个月。在4例LD患者中，3例患者在化疗结束后6个月内出现结节病，第4例患者在异基因骨髓移植后15个月出现结节病。在结节病诊断时，胸部没有恶性肿瘤的临床或病理证据。我们得出结论，与先前描述的LD之前的结节病综合征相反，存在恶性肿瘤之后伴或不伴化疗的结节病综合征。
