深入研究散发性黑色素瘤中的体细胞变异。
Delving into somatic variation in sporadic melanoma.
机构信息
The Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Pigment Cell Melanoma Res. 2012 Mar;25(2):155-70. doi: 10.1111/j.1755-148X.2012.00976.x. Epub 2012 Feb 13.
Abstract
Melanoma, the most aggressive form of skin cancer, has increased in incidence more rapidly than any other cancer. The completion of the human genome project and advancements in genomics technologies has allowed us to investigate genetic alterations of melanoma at a scale and depth that is unprecedented. Here, we survey the history of the different approaches taken to understand the genomics of melanoma - from early candidate genes, to gene families, to genome-wide studies. The new era of whole-exome and whole-genome sequencing has paved the way for an in-depth understanding of melanoma biology, identification of new therapeutic targets, and development of novel personalized therapies for melanoma.
摘要
黑色素瘤是最具侵袭性的皮肤癌，其发病率增长速度比其他任何癌症都要快。人类基因组计划的完成和基因组学技术的进步使我们能够以前所未有的规模和深度研究黑色素瘤的遗传改变。在这里，我们调查了不同方法在理解黑色素瘤基因组学方面的历史 - 从早期的候选基因到基因家族，再到全基因组研究。全外显子组和全基因组测序的新时代为深入了解黑色素瘤生物学、鉴定新的治疗靶点以及开发新型个性化黑色素瘤治疗方法铺平了道路。
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