Zhang Di, Zhu Rongrong, Zhang Hanqian, Zheng Chun-Hou, Xia Junfeng
Institute of Health Sciences, School of Computer Science and Technology.
College of Electrical Engineering and Automation and Center of Information Support and Assurance Technology, Anhui University, Hefei, Anhui 230601, China.
Database (Oxford). 2015 Sep 30;2015. doi: 10.1093/database/bav097. Print 2015.
The Melanoma Gene Database (MGDB) is a manually curated catalog of molecular genetic data relating to genes involved in melanoma. The main purpose of this database is to establish a network of melanoma related genes and to facilitate the mechanistic study of melanoma tumorigenesis. The entries describing the relationships between melanoma and genes in the current release were manually extracted from PubMed abstracts, which contains cumulative to date 527 human melanoma genes (422 protein-coding and 105 non-coding genes). Each melanoma gene was annotated in seven different aspects (General Information, Expression, Methylation, Mutation, Interaction, Pathway and Drug). In addition, manually curated literature references have also been provided to support the inclusion of the gene in MGDB and establish its association with melanoma. MGDB has a user-friendly web interface with multiple browse and search functions. We hoped MGDB will enrich our knowledge about melanoma genetics and serve as a useful complement to the existing public resources. Database URL: http://bioinfo.ahu.edu.cn:8080/Melanoma/index.jsp.
黑色素瘤基因数据库（MGDB）是一个人工整理的、与黑色素瘤相关基因的分子遗传数据目录。该数据库的主要目的是建立一个黑色素瘤相关基因网络，并促进黑色素瘤肿瘤发生的机制研究。当前版本中描述黑色素瘤与基因之间关系的条目是从PubMed摘要中手动提取的，截至目前共包含527个人类黑色素瘤基因（422个蛋白质编码基因和105个非编码基因）。每个黑色素瘤基因都从七个不同方面进行了注释（一般信息、表达、甲基化、突变、相互作用、通路和药物）。此外，还提供了人工整理的文献参考资料，以支持该基因被纳入MGDB并确立其与黑色素瘤的关联。MGDB拥有一个用户友好的网络界面，具备多种浏览和搜索功能。我们希望MGDB能丰富我们对黑色素瘤遗传学的认识，并作为现有公共资源的有益补充。数据库网址：http://bioinfo.ahu.edu.cn:8080/Melanoma/index.jsp。
