Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185 Uppsala, Sweden.
Biochem Soc Trans. 2012 Feb;40(1):20-5. doi: 10.1042/BST20110689.
VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) associate with the ligand-receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve tissue growth and inflammation, such as cancer. The present review outlines the current understanding of NRPs in relation to blood and lymphatic vessel biology.
VEGFs（血管内皮生长因子）是血管发育以及成人健康和疾病期间血液和淋巴管功能的主要调节因子。这个家族有五个哺乳动物配体，通过三个 RTKs（受体酪氨酸激酶）发挥作用。此外，共受体（如神经纤毛蛋白）与配体-受体信号复合物结合并调节输出。为了阻止涉及组织生长和炎症的疾病（如癌症）中的血管形成、血管生成，已经开发了几种阻断 VEGF 信号成分和 NRP 功能的治疗药物。本文综述了 NRP 与血液和淋巴管生物学关系的最新认识。
