血管内皮生长因子受体的信号转导。
Signal transduction by vascular endothelial growth factor receptors.
机构信息
Uppsala University, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, 751 85 Uppsala, Sweden.
出版信息
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006502. doi: 10.1101/cshperspect.a006502.
Abstract
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs). In addition, coreceptors like neuropilins (NRPs) and integrins associate with the ligand/receptor signaling complex and modulate the output. Therapeutics to block several of the VEGF signaling components have been developed with the aim to halt blood vessel formation, angiogenesis, in diseases that involve tissue growth and inflammation, such as cancer. In this review, we outline the current information on VEGF signal transduction in relation to blood and lymphatic vessel biology.
摘要
血管内皮生长因子 (VEGFs) 是血管发育以及成人健康和疾病期间血液和淋巴管功能的主要调节因子。因此，了解这五种哺乳动物配体的作用机制非常重要，这些配体通过三种受体酪氨酸激酶 (RTKs) 发挥作用。此外，神经纤毛蛋白 (NRPs) 和整合素等辅助受体与配体/受体信号复合物结合并调节输出。为了阻止涉及组织生长和炎症的疾病（如癌症）中的血管形成、血管生成，已经开发出了几种阻断 VEGF 信号传导成分的治疗方法。在这篇综述中，我们概述了与血液和淋巴管生物学有关的 VEGF 信号转导的最新信息。
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