甘油磷酸肌醇及其细胞功能。

The glycerophosphoinositols and their cellular functions.

机构信息

Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy.

出版信息

Biochem Soc Trans. 2012 Feb;40(1):101-7. doi: 10.1042/BST20110679.

DOI:10.1042/BST20110679

Abstract

Interest in the glycerophosphoinositols has been increasing recently, on the basis of their biological activities. The cellular metabolism of these water-soluble bioactive phosphoinositide metabolites has been clarified, with the identification of the specific enzyme involved in their synthesis, PLA2IVα (phospholipase A2 IVα), and the definition of their phosphodiesterase-based catabolism, and thus inactivation. The functional roles and mechanisms of action of these compounds have been investigated in different cellular contexts. This has led to their definition in the control of various cell functions, such as cell proliferation in the thyroid and actin cytoskeleton organization in fibroblasts and lymphocytes. Roles for the glycerophosphoinositols in immune and inflammatory responses are also being defined. In addition to these physiological functions, the glycerophosphoinositols have potential anti-metastatic activities that should lead to their pharmacological exploitation.

摘要

最近，基于其生物活性，人们对甘油磷酸肌醇的兴趣日益增加。这些水溶性生物活性磷酸肌醇代谢物的细胞代谢已经得到阐明，涉及它们合成的特定酶，即 PLA2IVα（磷脂酶 A2 IVα），以及基于磷酸二酯酶的分解代谢和失活已经得到定义。这些化合物在不同细胞环境中的功能作用和作用机制已经被研究过。这导致了它们在控制各种细胞功能（如甲状腺细胞增殖和成纤维细胞和淋巴细胞中肌动蛋白细胞骨架组织）中的定义。甘油磷酸肌醇在免疫和炎症反应中的作用也正在被定义。除了这些生理功能外，甘油磷酸肌醇还具有潜在的抗转移活性，这应该导致它们在药理学上的开发利用。