Stühlinger W, Innerebner M, Aberer W
Abteilung für Innere Medizin, Universitäts-Hautklinik Wien.
Dtsch Med Wochenschr. 1990 Nov 9;115(45):1712-5. doi: 10.1055/s-2008-1065215.
Two sisters, aged 25 and 29 years, with generalized psoriasis guttata since childhood, developed nausea, upper-abdominal pain, loss of appetite, palpitations and flushes in the course of local and oral administration of fumaric acid esters. Because of these side effects the treatment was discontinued after about two weeks, and the symptoms disappeared. But proteinuria and haematuria were subsequently noted, creatinine concentration rose to 2.2 and 2.5 mg/dl, respectively, while creatinine clearance fell to 44 and 27 ml/min, respectively. Examination of urinary sediments and analysis of urinary proteins gave results compatible with tubular-interstitial renal damage. The abnormal renal functions and urinary findings proved reversible within three weeks.
两名姐妹，分别为25岁和29岁，自幼患有泛发性点滴状银屑病，在局部和口服富马酸酯治疗过程中出现恶心、上腹部疼痛、食欲不振、心悸和潮热。由于这些副作用，治疗在大约两周后停止，症状消失。但随后发现蛋白尿和血尿，肌酐浓度分别升至2.2和2.5mg/dl，而肌酐清除率分别降至44和27ml/min。尿沉渣检查和尿蛋白分析结果与肾小管间质性肾损伤相符。肾功能异常和尿液检查结果在三周内证明是可逆的。
