[正常人白细胞表面膜及淋巴增殖性疾病中与单克隆抗体IB4相互作用的抗原的表达]

[The expression of an antigen interacting with monoclonal antibody IB4 on the surface membranes of normal human leukocytes and in lymphoproliferative diseases].

作者信息

Filatov A V, Bachurin P S, Sidorenko S P, Abramenko I V, Gluzman D F

出版信息

Eksp Onkol. 1990;12(5):40-3.

Abstract

Monoclonal antibody (MAb) 1B4 of IgG3 isotype reacting with 55 +/- 10% peripheral blood lymphocytes was obtained. MAb 1B4 is bound with 100% of B and NK cells and 50-70% of T cells in blood. The most part of CD8+ cells (60-100%) and approximately 50% of CD4+ cells belong to 1B4+ population. T-ALL cells do not express 1B4 antigen. Analysis of reactivity of MAb 1B4 with transformed malignant cells has shown that 1B4 antigen appeared in the process of differentiation of B lymphocytes at the state of pre-B cells and disappeared with activation of B lymphocytes and transition to plasma cells.

摘要

获得了与55±10%的外周血淋巴细胞发生反应的IgG3同种型单克隆抗体（MAb）1B4。MAb 1B4与血液中100%的B细胞和NK细胞以及50 - 70%的T细胞结合。CD8 +细胞的大部分（60 - 100%）和约50%的CD4 +细胞属于1B4 +群体。T - ALL细胞不表达1B4抗原。对MAb 1B4与转化的恶性细胞的反应性分析表明，1B4抗原在B淋巴细胞分化至前B细胞状态的过程中出现，并随着B淋巴细胞的活化和向浆细胞的转变而消失。

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