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用单克隆抗体FMC7检测成熟人B细胞的抗原：抗原性质及其表达调控的研究

The antigen of mature human B cells detected by the monoclonal antibody FMC7: studies on the nature of the antigen and modulation of its expression.

作者信息

Zola H, Moore H A, Hohmann A, Hunter I K, Nikoloutsopoulos A, Bradley J

出版信息

J Immunol. 1984 Jul;133(1):321-6.

PMID:6427340
Abstract

The monoclonal antibody FMC7 delineates a subpopulation of B lymphocytes in normal blood. Expression of the antigen recognized by FMC7 appears to be maturation-linked, and it serves to distinguish different types of B cell leukemia. The data presented here indicate that the antigen is a protein that is integrated in the cell membrane and that is able to interact with the cytoskeleton. The antigen is rapidly synthesized and turned over, is not cell cycle-dependent, and is relatively resistant to changes induced by culture in the presence of a phorbol ester.

摘要

单克隆抗体FMC7可识别正常血液中的B淋巴细胞亚群。FMC7所识别抗原的表达似乎与细胞成熟相关，并且可用于区分不同类型的B细胞白血病。本文所提供的数据表明，该抗原是一种整合于细胞膜且能与细胞骨架相互作用的蛋白质。该抗原合成迅速且更新快，不依赖细胞周期，并且相对抵抗佛波酯培养诱导的变化。

相似文献

1
The antigen of mature human B cells detected by the monoclonal antibody FMC7: studies on the nature of the antigen and modulation of its expression.用单克隆抗体FMC7检测成熟人B细胞的抗原：抗原性质及其表达调控的研究
J Immunol. 1984 Jul;133(1):321-6.
2
Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression.人淋巴细胞分化抗原HB - 10和HB - 11。I.抗原表达的个体发生。
J Immunol. 1985 May;134(5):2983-8.
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Modulation of expression of the antigen identified by FMC7 upon human B-lymphocyte activation: evidence for differences between activation in vivo and in vitro.FMC7识别的抗原在人B淋巴细胞活化时的表达调控：体内与体外活化差异的证据
Immunology. 1990 Mar;69(3):373-8.
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Maturation of human B lymphocytes--studies with a panel of monoclonal antibodies against membrane antigens.人类B淋巴细胞的成熟——使用一组抗膜抗原单克隆抗体的研究
Clin Exp Immunol. 1983 Jun;52(3):655-64.
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A unique antigen on mature B cells defined by a monoclonal antibody.一种由单克隆抗体定义的成熟B细胞上的独特抗原。
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Identification of an early activation antigen (Bac-1) on human B cells.人类B细胞上一种早期激活抗原（Bac-1）的鉴定。
J Immunol. 1986 Aug 15;137(4):1208-13.
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Antibody-induced antigenic modulation is antigen dependent: characterization of 22 proteins on a malignant human B cell line.抗体诱导的抗原调变是抗原依赖性的：对一种恶性人B细胞系上22种蛋白质的特性分析
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Altered expression of cell surface membrane antigens in a common acute lymphoblastic leukemia-associated antigen-expressing neuroblastoma cell line (SJ-N-CG) with morphological differentiation.在具有形态分化的常见急性淋巴细胞白血病相关抗原表达神经母细胞瘤细胞系（SJ-N-CG）中细胞表面膜抗原的表达改变。
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A monoclonal antibody with reactivity restricted to normal and neoplastic plasma cells.一种反应性仅限于正常和肿瘤性浆细胞的单克隆抗体。
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引用本文的文献

1
Bone marrow histopathologic patterns and immunologic phenotype in B-cell chronic lymphocytic leukaemia.
Blut. 1988 Jul;57(1):19-23. doi: 10.1007/BF00320630.
2
A human monoclonal antibody recognizing a surface antigen on stomach cancer cells.一种识别胃癌细胞表面抗原的人源单克隆抗体。
Jpn J Cancer Res. 1989 Jun;80(6):546-53. doi: 10.1111/j.1349-7006.1989.tb01674.x.
3
An activation antigen on a subpopulation of B lymphocytes identified by the monoclonal antibody CMRF-17.一种由单克隆抗体CMRF - 17识别的B淋巴细胞亚群上的活化抗原。
Immunology. 1989 Jul;67(3):351-8.
4
Membrane phenotypic studies in B cell lymphoproliferative disorders.B细胞淋巴增殖性疾病的膜表型研究。
J Clin Pathol. 1985 Sep;38(9):995-1001. doi: 10.1136/jcp.38.9.995.
5
Modulation of expression of the antigen identified by FMC7 upon human B-lymphocyte activation: evidence for differences between activation in vivo and in vitro.FMC7识别的抗原在人B淋巴细胞活化时的表达调控：体内与体外活化差异的证据
Immunology. 1990 Mar;69(3):373-8.