Vislobokov A I, Losev N A, Zaĭtsev Iu V
Fiziol Zh SSSR Im I M Sechenova. 1979 Apr;65(4):549-56.
In experiments on Limnae stagnalis neurons, ethymisol increased the AP duration while reducing the trace hyperpolarization and the rate of development of the AP descending phase. Ethymisol (10 mM/1) induced either hyperpolarization of neurons with an increase in membrane resistance or their depolarization (20 mM/1) with a decrease in membrane resistance. A drop in the medium temperature by 2-4 degrees C prevented the hyperpolarization. The ethymisol-induced hyperpolarization seems to be connected with a decrease in membrane permeability for sodium ions in resting conditions and with activation of electrogenic ion transport. The increase of extraneuronal potassium up to 4 mM/1 and depolarization induced by currents of 1-3 nA intensified the ethymisol effects. Ethymisol decreased efflux and influx of ions through membrane thus affecting the AP parameters. The effects of ethymisol also involved an increase of neurons excitability and intensification of synaptic activity. Neither ethyrasol nor caffein exerted these effects.
在用静水椎实螺神经元进行的实验中，乙嘧酚增加了动作电位（AP）的持续时间，同时减少了微量超极化和AP下降相的发展速率。乙嘧酚（10 mM/1）可诱导神经元超极化并伴有膜电阻增加，或使其去极化（20 mM/1）并伴有膜电阻降低。培养基温度下降2 - 4摄氏度可阻止超极化。乙嘧酚诱导的超极化似乎与静息状态下膜对钠离子的通透性降低以及电生性离子转运的激活有关。细胞外钾离子浓度增加至4 mM/1以及1 - 3 nA电流诱导的去极化会增强乙嘧酚的作用。乙嘧酚减少了离子通过膜的外流和内流，从而影响AP参数。乙嘧酚的作用还包括增加神经元兴奋性和增强突触活动。乙嘧唑和咖啡因均未产生这些作用。
