Agashe Hrushikesh, Hu Minlu, Rohan Lisa
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Curr HIV Res. 2012 Jan 1;10(1):88-96. doi: 10.2174/157016212799304599.
The development of pre-exposure prophylactics or microbicide products for the reduction or elimination of the sexual transmission of HIV has numerous challenges or barriers to success. Historically traditional dosage forms such as gels have been developed in the field but more recently controlled release dosage forms such as vaginal rings and novel dosage forms such as polymeric thin films have been studied. Studies have begun to incorporate scientific strategies into the formulation design of microbicide products in order to develop safer and more effective products. In addition advanced drug delivery strategies to overcome barriers to delivery and specific drug targeting methods are being employed. In the present review, a comprehensive discussion of formulation efforts and novel delivery strategies in the field of microbicide product development is presented.
开发用于减少或消除艾滋病毒性传播的暴露前预防药物或杀微生物剂产品面临诸多挑战或成功障碍。从历史上看，该领域已开发出凝胶等传统剂型，但最近也对阴道环等控释剂型以及聚合物薄膜等新型剂型进行了研究。研究已开始将科学策略纳入杀微生物剂产品的配方设计中，以开发更安全、更有效的产品。此外，正在采用先进的药物递送策略来克服递送障碍，并运用特定的药物靶向方法。在本综述中，对杀微生物剂产品开发领域的配方研究和新型递送策略进行了全面讨论。
