Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
Org Lett. 2012 Feb 3;14(3):848-51. doi: 10.1021/ol2033652. Epub 2012 Jan 20.
The use of perfluorooctylpropylsulfonylethanol as a new phosphate protecting group and fluorous linker is evaluated in the stepwise solution phase synthesis of a number of biologically relevant (carbohydrate substituted) glycerol teichoic acid fragments. Teichoic acid fragments, up to the dodecamer level, were assembled by means of phosphoramidite chemistry, using a relatively small excess of the building blocks and a repetitive efficient purification procedure of the protected intermediates by fluorous solid phase extraction (F-SPE).
评价了全氟辛基丙基磺酰乙氧基乙醇作为一种新的磷酸保护基和氟烷基连接体，用于一系列具有生物相关性（碳水化合物取代）的甘油磷壁酸片段的逐步溶液相合成。采用亚磷酰胺化学，使用相对过量的构建块和通过氟固相萃取（F-SPE）对保护中间体进行重复有效的纯化，可将磷壁酸片段组装至十二聚体水平。
