Froc：一种用于肽和寡糖合成的新型氟代保护基。

Froc: a new fluorous protective group for peptide and oligosaccharide synthesis.

作者信息

Manzoni Leonardo, Castelli Riccardo

机构信息

C.N.R. - Istituto di Scienze e Tecnologie Molecolari (ISTM) and Centro Interdisciplinare Studi Biomolecolari e applicazioni Industriali (CISI), Via Venezian 21, I-20133 Milano, Italy.

出版信息

Org Lett. 2006 Mar 2;8(5):955-7. doi: 10.1021/ol060006e.

DOI:10.1021/ol060006e

PMID:16494483

Abstract

The synthesis of a new fluorous protecting group, Froc, is described. This new fluorous tag has been used in peptide and carbohydrate synthesis by our group and readily allows us to fully characterize each product (NMR, MS) and monitor each synthetic step by TLC. Purification of the products is generally performed by standard fluorous solid-phase extraction techniques (e.g., F-SPE), but standard chromatographic purifications are also possible if required.

摘要

本文描述了一种新型含氟保护基Froc的合成方法。我们团队已将这种新型含氟标签用于肽和碳水化合物的合成中，它能让我们轻松地对每种产物进行全面表征（核磁共振、质谱），并通过薄层色谱法监测每一步合成过程。产物的纯化一般采用标准的含氟固相萃取技术（如氟固相萃取），但如有需要，也可采用标准的色谱纯化方法。