Goodman Cancer Centre, McGill University, 1160 Pine Avenue West, Montreal, Québec, Canada.
Breast Cancer Res. 2011;13(6):229. doi: 10.1186/bcr2905. Epub 2011 Nov 30.
Consistent with their essential role in cell adhesion to the extracellular matrix, integrins and their associated signaling pathways have been shown to be involved in cell proliferation, migration, invasion and survival, processes required in both tumorigenesis and metastasis. β1-integrins represent the predominantly expressed integrins in mammary epithelial cells and have been proven crucial for mammary gland development and differentiation. Here we provide an overview of the studies that have used transgenic mouse models of mammary tumorigenesis to establish β1-integrin as a critical mediator of breast cancer progression and thereby as a potential therapeutic target for the development of new anticancer strategies.
与细胞黏附到细胞外基质的基本作用一致，整合素及其相关信号通路已被证明参与细胞增殖、迁移、浸润和存活等过程，这些过程在肿瘤发生和转移中都需要。β1 整合素是乳腺上皮细胞中表达最丰富的整合素，已被证明对乳腺发育和分化至关重要。在这里，我们概述了使用乳腺肿瘤发生的转基因小鼠模型的研究，这些研究确立了β1 整合素作为乳腺癌进展的关键介质，从而成为开发新抗癌策略的潜在治疗靶点。
