MIMSR Medical College and YCR Hospital, Latur, Maharashtra, India.
Int Wound J. 2012 Oct;9(5):553-6. doi: 10.1111/j.1742-481X.2011.00914.x. Epub 2012 Jan 20.
A prospective study was carried out to assess the role of citric acid as a sole antimicrobial agent in the management of lepromatous ulcers. Thirty-four known cases of lepromatous ulcers not responding to conventional antibiotic therapies for long duration were investigated for culture and susceptibility studies. Staphylococcus aureus (25·00%) and Klebsiella spp. (23·43%) were found to be the most common isolates. Amikacin (68·75%) and ciprofloxacin (67·18%) were found to be the most effective antimicrobial agents. Topical application of citric acid ointment resulted in complete healing in 25 (73·52%) cases. In eight cases (26·48%), there was elimination of infective agent from ulcer site and formation of healthy granulation, but no complete healing of ulcer was seen. Results indicate that citric acid is the best alternative for the effective management of lepromatous ulcers when other therapies are exhausted.
一项前瞻性研究评估了柠檬酸作为单一抗菌剂在麻风性溃疡治疗中的作用。对 34 例长期未能对常规抗生素治疗产生反应的麻风性溃疡进行了培养和药敏研究。结果发现，金黄色葡萄球菌（25.00%）和克雷伯菌属（23.43%）是最常见的分离株。阿米卡星（68.75%）和环丙沙星（67.18%）被发现是最有效的抗菌药物。柠檬酸软膏的局部应用导致 25 例（73.52%）患者完全愈合。在 8 例（26.48%）患者中，溃疡部位的感染因子被消除并形成了健康的肉芽组织，但溃疡没有完全愈合。结果表明，当其他治疗方法无效时，柠檬酸是治疗麻风性溃疡的最佳选择。
