School of Psychological Science, La Trobe University, Melbourne, Victoria, Australia.
J Int Neuropsychol Soc. 2012 Mar;18(2):295-304. doi: 10.1017/S135561771100172X. Epub 2012 Jan 23.
Recent research has established that individuals with amnestic mild cognitive impairment (aMCI) have impaired prospective memory (PM); however, findings regarding differential deficits on time-based versus event-based PM have been less clear. Furthermore, the diagnostic utility of PM measures has received scant attention. Healthy older adults (n = 84) and individuals with aMCI (n = 84) were compared on the Cambridge Prospective Memory Test (CAMPROMPT) and two single-trial event-based PM tasks. The aMCI participants showed global impairment on all PM measures. Measures of retrospective memory and complex attention predicted both time and event PM performance for the aMCI group. Each of the PM measures was useful for discriminating aMCI from healthy older adults and the time- and event-based scales of the CAMPROMPT were equivalent in their discriminative ability. Surprisingly, the brief PM tasks were as good as more comprehensive measures of PM (CAMPROMPT) at predicting aMCI. Results indicate that single-trial PM measures, easily integrated into clinical practice, may be useful screening tools for identifying aMCI. As PM requires retrospective memory skills along with complex attention and executive skills, the interaction between these skills may explain the global PM deficits in aMCI and the good discriminative ability of PM for diagnosing aMCI.
最近的研究已经证实，患有健忘型轻度认知障碍（aMCI）的个体的前瞻性记忆（PM）受损；然而，关于基于时间和基于事件的 PM 差异缺陷的发现还不太清楚。此外，PM 测量的诊断效用很少受到关注。将 84 名健康老年人和 84 名 aMCI 患者（n = 84）在剑桥前瞻性记忆测试（CAMPROMPT）和两个基于单试事件的 PM 任务上进行比较。aMCI 参与者在所有 PM 测量上都表现出整体损伤。回溯记忆和复杂注意力的测量预测了 aMCI 组的时间和事件 PM 表现。PM 测量中的每一项都有助于将 aMCI 与健康老年人区分开来，并且 CAMPROMPT 的基于时间和基于事件的量表在其区分能力方面是等效的。令人惊讶的是，简短的 PM 任务与更全面的 PM 测量（CAMPROMPT）一样，能够很好地预测 aMCI。结果表明，易于整合到临床实践中的单试 PM 测量可能是识别 aMCI 的有用筛选工具。由于 PM 需要回溯记忆技能以及复杂注意力和执行技能，因此这些技能之间的相互作用可能解释了 aMCI 中全局 PM 缺陷以及 PM 诊断 aMCI 的良好区分能力。
