Centre de Regulació Genòmica and UPF, Barcelona, Spain.
Cancer Cell. 2012 Jan 17;21(1):5-7. doi: 10.1016/j.ccr.2011.12.019.
The mechanisms leading to the constitutive activation of NF-κB in cancers and the pathways upstream and downstream of this activation are not fully understood. In this issue of Cancer Cell, Yamagishi et al. demonstrate that Polycomb-mediated silencing of miR-31 is implicated in the aberrant activation of NF-κB signaling in tumors.
导致癌症中 NF-κB 组成性激活的机制以及该激活的上游和下游途径尚未完全阐明。在本期《癌细胞》杂志中，Yamagishi 等人证明，多梳体介导的 miR-31 的沉默与肿瘤中 NF-κB 信号的异常激活有关。
