State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute (CAAS), Lanzhou, China.
College of Life Science and Technology, Xinjiang University, Urumqi, China.
Front Immunol. 2018 Mar 19;9:546. doi: 10.3389/fimmu.2018.00546. eCollection 2018.
Nuclear factor kappa B (NF-κB) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression. NF-κB expression is transient and tightly regulated in normal cells, but it is activated in cancer cells. Recently, numerous studies have demonstrated microRNAs (miRNAs) play a vital role in the NF-κB signaling pathway and NF-κB-associated immune responses, radioresistance and drug resistance of cancer, some acting as inhibitors and the others as activators. Although it is still in infancy, targeting NF-κB or the NF-κB signaling pathway by miRNAs is becoming a promising strategy of cancer treatment.
核因子 kappa B（NF-κB）是一种多能且关键的二聚体转录因子，它协调各种生理和病理过程，特别是细胞增殖、炎症以及癌症的发生和发展。NF-κB 在正常细胞中的表达是短暂且受到严格调控的，但在癌细胞中被激活。最近，大量研究表明 microRNAs（miRNAs）在 NF-κB 信号通路和 NF-κB 相关免疫反应、癌症的放射抵抗和耐药性中发挥重要作用，其中一些作为抑制剂，另一些作为激活剂。尽管这仍处于起步阶段，但通过 miRNAs 靶向 NF-κB 或 NF-κB 信号通路正成为癌症治疗的一种有前途的策略。
