Department of Reproductive Medicine, St Mary's Hospital, Manchester, United Kingdom.
Fertil Steril. 2012 Mar;97(3):677-81. doi: 10.1016/j.fertnstert.2011.12.040. Epub 2012 Jan 21.
To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antimüllerian hormone, antral follicle count, FSH).
Prospective observational study.
Tertiary referral center for reproductive medicine.
PATIENT(S): Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF.
INTERVENTION(S): Baseline pelvic ultrasound and blood tests were taken on day 2-3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays.
MAIN OUTCOME MEASURE(S): Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve.
RESULT(S): There was no evidence of any difference in basal FSH, antimüllerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index.
CONCLUSION(S): No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort.
评估卵泡刺激素受体（FSHR）基因变异与当前卵巢储备标志物（抗苗勒管激素、窦卵泡计数、FSH）之间的关联。
前瞻性观察性研究。
生殖医学三级转诊中心。
接受 IVF 控制性卵巢刺激的首次周期的女性（n=421）。
在周期的第 2-3 天进行基线盆腔超声和血液检查，以评估基线激素水平并提取 DNA。使用 TaqMan 等位基因鉴别检测确定 FSHR p.Asn680Ser 和 p.Thr307Ala 变体的基因型。
FSHR 单核苷酸多态性与卵巢储备标志物的相关性。
无论是否调整年龄或体重指数，不同基因型患者的基础 FSH、抗苗勒管激素或窦卵泡计数均无差异。
在本队列中，未发现 FSHR 基因型与卵巢储备标志物之间存在关联。
