Drakopoulos Panagiotis, Bardhi Erlisa, Boudry Liese, Vaiarelli Alberto, Makrigiannakis Antonis, Esteves Sandro C, Tournaye Herman, Blockeel Christophe
Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion, Greece.
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Ther Adv Reprod Health. 2020 Jul 31;14:2633494120941480. doi: 10.1177/2633494120941480. eCollection 2020 Jan-Dec.
Despite the considerate progress to which assisted reproduction technology (ART) has been subject since 1978, some issues remain unresolved. Notably, the clinical management of patients with a poor ovarian response is still a challenge in everyday practice, frustrating to both the patient and the fertility expert. Poor ovarian responders (PORs) embody 9-24% of patients undergoing ovarian stimulation, meaning that up to one in four patients conceals a poor reproductive prognosis. The last decade has witnessed the attempts of the medical community to standardize diagnosis of POR with the developing of the Bologna Criteria and the subsequent evolution of the low prognosis patient elaborated in the POSEIDON classification. The aim of this article is to summarize all evidence concerning etiology and management of poor ovarian response, including the most recent advances and future prospects in this regard.
尽管自1978年以来辅助生殖技术（ART）取得了显著进展，但仍有一些问题尚未得到解决。值得注意的是，卵巢反应不良患者的临床管理在日常实践中仍然是一项挑战，这让患者和生育专家都感到沮丧。卵巢低反应者（PORs）占接受卵巢刺激患者的9%-24%，这意味着每四名患者中就有一名隐藏着不良的生殖预后。过去十年见证了医学界随着博洛尼亚标准的制定以及随后在波塞冬分类中阐述的低预后患者的演变，试图对POR的诊断进行标准化。本文的目的是总结有关卵巢反应不良的病因和管理的所有证据，包括这方面的最新进展和未来前景。
