Institut Jean-Pierre Bourgin, UMR1318 INRA-AgroParisTech, F-78000 Versailles, France.
Curr Opin Plant Biol. 2012 Apr;15(2):192-8. doi: 10.1016/j.pbi.2012.01.005. Epub 2012 Jan 20.
Even if considerable progress has been achieved towards the understanding of natural variation in plant systems, the contribution of transcript abundance variation to phenotypic diversity remains unappreciated. Over the last decade, efforts to characterise the genome-wide expression variation in natural accessions, structured populations and hybrids have improved our knowledge of the contribution of non-coding polymorphisms to gene expression regulation. Moreover, new studies are helping to unravel the role of expression polymorphisms and their orchestrated performance. Recent advances involving classical linkage analysis, GWAS and improved eQTL mapping strategies will provide a greater resolution to determine the genetic variants shaping the broad diversity in plant systems.
尽管在理解植物系统的自然变异方面已经取得了相当大的进展，但转录丰度变异对表型多样性的贡献仍未得到重视。在过去的十年中，人们努力描述自然群体、结构群体和杂种的全基因组表达变异，这提高了我们对非编码多态性对基因表达调控的贡献的认识。此外，新的研究正在帮助揭示表达多态性及其协调表现的作用。涉及经典连锁分析、GWAS 和改进的 eQTL 映射策略的最新进展将提供更大的分辨率，以确定塑造植物系统广泛多样性的遗传变异。
