Reichl D
St Bartholomew's Hospital, London, U.K.
Eur Heart J. 1990 Aug;11 Suppl E:230-6. doi: 10.1093/eurheartj/11.suppl_e.230.
The concentration of cholesterol in peripheral lymph is roughly one tenth of that in the blood plasma of the same subject. In lymph, there is virtually no very low density lipoprotein (VLDL), probably due to low permeability of the vascular endothelium for particles of this size. More than 95% of apo B-containing lipoproteins of lymph have the density of plasma low density lipoproteins (LDL). The concentration of apo A-I and apo A-II in lymph is about 15% of that in plasma; yet about 50% of the total mass of both these main HDL apoproteins is present extravascularly. High density lipoproteins (HDL) of lymph appear square-packing, and the presence of such large HDL particles is the most conspicuous difference between lipoproteins in plasma and in the extravascular fluids. It remains to be seen whether raising plasma apo A-I concentration per se will increase the initial stages of reverse cholesterol transport and also be clinically beneficial.
外周淋巴中胆固醇的浓度大约是同一受试者血浆中胆固醇浓度的十分之一。在淋巴中，几乎不存在极低密度脂蛋白（VLDL），这可能是由于血管内皮对这种大小的颗粒通透性较低。淋巴中超过95%含载脂蛋白B的脂蛋白具有血浆低密度脂蛋白（LDL）的密度。淋巴中载脂蛋白A-I和载脂蛋白A-II的浓度约为血浆中的15%；然而，这两种主要HDL载脂蛋白的总质量约50%存在于血管外。淋巴中的高密度脂蛋白（HDL）呈方形堆积，这种大的HDL颗粒的存在是血浆和血管外液中脂蛋白最显著的差异。提高血浆载脂蛋白A-I浓度本身是否会增加胆固醇逆向转运的初始阶段并在临床上有益，仍有待观察。
