Epilepsy Center Hessen, Department of Neurology, Philipps-University Marburg, Baldingerstr. 1, 35033 Marburg, Germany.
Seizure. 2012 Apr;21(3):227-8. doi: 10.1016/j.seizure.2011.12.009. Epub 2012 Jan 20.
Minocycline, a tetracycline family antibiotic, is known to inhibit microglial activation and proinflammatory cytokine release in animal models. Experimental data show that these immune processes may play a role in epilepto- and ictogenesis. We present the case of a patient with marked reduction in seizure frequency during minocycline therapy with severe symptomatic epilepsy due to an astrocytoma.
米诺环素是一种四环素类抗生素，已知可抑制动物模型中小胶质细胞的激活和促炎细胞因子的释放。实验数据表明，这些免疫过程可能在癫痫发生和发作形成中起作用。我们报告了一例因星形细胞瘤导致严重症状性癫痫的患者，在米诺环素治疗期间癫痫发作频率显著降低。
