米诺环素在一名患有星形细胞瘤和耐药性癫痫的患者中作为有效的抗惊厥药。

Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy.

机构信息

Epilepsy Center Hessen, Department of Neurology, Philipps-University Marburg, Baldingerstr. 1, 35033 Marburg, Germany.

出版信息

Seizure. 2012 Apr;21(3):227-8. doi: 10.1016/j.seizure.2011.12.009. Epub 2012 Jan 20.

DOI:10.1016/j.seizure.2011.12.009

Abstract

Minocycline, a tetracycline family antibiotic, is known to inhibit microglial activation and proinflammatory cytokine release in animal models. Experimental data show that these immune processes may play a role in epilepto- and ictogenesis. We present the case of a patient with marked reduction in seizure frequency during minocycline therapy with severe symptomatic epilepsy due to an astrocytoma.

摘要

米诺环素是一种四环素类抗生素，已知可抑制动物模型中小胶质细胞的激活和促炎细胞因子的释放。实验数据表明，这些免疫过程可能在癫痫发生和发作形成中起作用。我们报告了一例因星形细胞瘤导致严重症状性癫痫的患者，在米诺环素治疗期间癫痫发作频率显著降低。