国家老龄化研究所-阿尔茨海默病协会关于阿尔茨海默病神经病理学评估的指南。

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease.

机构信息

Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA.

出版信息

Alzheimers Dement. 2012 Jan;8(1):1-13. doi: 10.1016/j.jalz.2011.10.007.

DOI:10.1016/j.jalz.2011.10.007

PMID:22265587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3266529/

Abstract

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.

摘要

最近，来自美国和欧洲的一个共识小组召开会议，更新和修订了 1997 年关于老年人群中常见的阿尔茨海默病（AD）和其他脑部疾病的神经病理学评估的共识指南。新指南承认 AD 的临床前阶段，增强了 AD 的评估，包括淀粉样蛋白积累以及神经纤维缠结和神经原纤维缠结，为路易体病、血管性脑损伤、海马硬化和 TDP-43 包涵体的神经病理学评估制定了方案，并建议对病例进行标准检查及其临床病理相关性。