Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TN 37232-5505, USA.
Exp Hematol. 2012 Apr;40(4):263-7. doi: 10.1016/j.exphem.2012.01.006. Epub 2012 Jan 17.
The majority of patients after allogeneic stem cell transplantation (HSCT) are expected to have vitamin D deficiency early post HSCT due to poor nutritional status and limited sun exposure. The importance of vitamin D in the immune system has been well defined during the past several years, as vitamin D has demonstrated modulatory effects on the immune system through B and T-lymphocyte, macrophage, monocyte, and dendritic cell regulations, which are the effector cells involved in graft-versus-host-disease (GVHD) pathophysiology after HSCT. High-dose early replacement of vitamin D might attenuate autoimmune reactions and decrease severity of GVHD. In this article, we discuss the hypothetical link between early vitamin D deficiency and GVHD and its potential therapeutic role in GVHD and long-term bone loss after HSCT.
由于营养状况不佳和阳光照射有限，大多数异基因干细胞移植（HSCT）后的患者预计在 HSCT 后早期会出现维生素 D 缺乏。近年来，维生素 D 在免疫系统中的重要性已经得到充分证明，因为维生素 D 通过 B 和 T 淋巴细胞、巨噬细胞、单核细胞和树突状细胞的调节对免疫系统具有调节作用，这些细胞是 HSCT 后移植物抗宿主病（GVHD）发病机制中的效应细胞。早期大剂量补充维生素 D 可能会减轻自身免疫反应并降低 GVHD 的严重程度。本文讨论了早期维生素 D 缺乏与 GVHD 之间的假设联系及其在 GVHD 和 HSCT 后长期骨质流失中的潜在治疗作用。
