Prince Henry's Institute, Clayton, Victoria 3168, Australia.
J Steroid Biochem Mol Biol. 2012 Jul;130(3-5):138-46. doi: 10.1016/j.jsbmb.2011.12.017. Epub 2012 Jan 14.
Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.
肝受体同源物-1（LRH-1；NR5A2）属于孤儿核受体超家族，在早期发育、胆固醇稳态、类固醇生成以及包括癌症在内的某些疾病中发挥着重要作用。它在胚胎干细胞、成年肝脏、肠道、胰腺和卵巢中表达。它作为单体与 DNA 结合，并受各种配体依赖和非依赖机制的调节。最近的研究工作确定了 LRH-1 的合成配体；这些化合物可能为与 LRH-1 表达和活性异常相关的一系列病理状况提供有用的治疗方法。
