Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Cardiovasc Res. 2012 Mar 15;93(4):563-72. doi: 10.1093/cvr/cvs013. Epub 2012 Jan 19.
MicroRNAs refer to a subfamily of small non-coding RNA species that are designed to influence gene expression in nearly all cell types studied to date. Studies from the past decade have demonstrated that microRNAs are atypically expressed in the cardiovascular system under specific pathological conditions. Gain- and loss-of-function studies using in vitro and in vivo models have revealed distinct roles for specific microRNAs in cardiovascular development, physiological functions, and cardiac pathological conditions. In this review, the current relevant findings on the role of microRNAs in cardiac hypertrophic growth are updated, the target genes of these microRNAs are summarized, and the future of microRNAs as potential therapeutic targets is discussed.
MicroRNAs 是一小类非编码 RNA 分子，它们的设计目的是影响迄今为止研究过的几乎所有细胞类型中的基因表达。过去十年的研究表明，microRNAs 在特定病理条件下的心血管系统中异常表达。使用体外和体内模型的增益和失能研究揭示了特定 microRNAs 在心血管发育、生理功能和心脏病理条件中的独特作用。在这篇综述中，更新了 microRNAs 在心脏肥厚生长中的作用的最新相关发现，总结了这些 microRNAs 的靶基因，并讨论了 microRNAs 作为潜在治疗靶点的未来。
