Ostrovskiĭ S Iu, Gorenshteĭn B I, Dosta G A, Karaedova L M, Nefedov L I
Farmakol Toksikol. 1990 Jul-Aug;53(4):63-5.
A single administration to rats of cyanamide (60 mg/kg, for 1 hour) was found to decrease the contents of cysteate, serine, glutamate, glycine, alanine, valine, methionine, isoleucine, tyrosine, ethanolamine, ornithine and histidine that may be considered as a manifestation on the drug hepatotoxicity. The activities of transaminases, glutamate dehydrogenase, pyruvate dehydrogenase remained unchanged. Cyanamide effects were considerably abolished by the supplementary ethanol administration (0.5 g/kg). Cyanamide failed to affect vitamin-dependent enzymes reflecting thiamine pyrophosphate, pyridoxal phosphate and flavine adenine dinucleotide status of the rat organism.
给大鼠单次给予氨基氰（60毫克/千克，持续1小时）后，发现半胱氨酸、丝氨酸、谷氨酸、甘氨酸、丙氨酸、缬氨酸、蛋氨酸、异亮氨酸、酪氨酸、乙醇胺、鸟氨酸和组氨酸的含量降低，这可能被视为药物肝毒性的一种表现。转氨酶、谷氨酸脱氢酶、丙酮酸脱氢酶的活性保持不变。补充乙醇（0.5克/千克）后，氨基氰的作用大为消除。氨基氰未能影响反映大鼠机体焦磷酸硫胺素、磷酸吡哆醛和黄素腺嘌呤二核苷酸状态的维生素依赖性酶。
