Ostrovskiĭ S Iu
Farmakol Toksikol. 1987 Jan-Feb;50(1):30-3.
Disulfiram (DS) (200 mg/kg for 3 days) decreases contents of GABA, phenylalanine, histidine, cystathionine, methionine, ornithine, leucine and lysine. The effect of DS is potentiated by ethanol (1 g/kg). In this case concentrations of alanine, valine, isoleucine and tyrosine additionally fall. Probable roles of GABA-ergic system and amino acids--precursors, neurotransmitters in the realization of therapeutic and, perhaps, side effects of DS are discussed. Additive effects of DS and its combination with ethanol indicates a significant contribution of acetaldehyde to the mentioned changes.
双硫仑（DS）（200毫克/千克，持续3天）可降低γ-氨基丁酸、苯丙氨酸、组氨酸、胱硫醚、蛋氨酸、鸟氨酸、亮氨酸和赖氨酸的含量。乙醇（1克/千克）可增强DS的作用。在这种情况下，丙氨酸、缬氨酸、异亮氨酸和酪氨酸的浓度会进一步下降。文中讨论了γ-氨基丁酸能系统和氨基酸（前体、神经递质）在DS治疗作用及可能的副作用实现过程中的潜在作用。DS及其与乙醇联合使用的相加作用表明乙醛对上述变化有显著影响。
