Larionov P M, Chernyavskii A M, Novruzov R B, Lushnikova E L, Subbotin D V, Sergeevichev D S, Kuznetsova I V, Karas'kov A M, Nepomnyashchikh L M
E. N. Meshalkin Research Institute of Circulatory Pathology, Federal Agency for High-Technological Medical Care, Novosibirsk, Russia.
Bull Exp Biol Med. 2011 Feb;150(4):530-4. doi: 10.1007/s10517-011-1183-5.
We studied angiogenic effects of two variants of indirect revascularization (transplantation of mononuclear fraction cells from autologous bone marrow alone or in combination with laser tunneling) after modeled ischemia of the lower limbs in rats. Doppler sonography and immunofluorescence studies showed that intramuscular implantation of isolated fraction of autologous bone marrow mononuclear cells in combination with laser tunneling of the muscles is most effective and can be recommended as a method of angiogenesis stimulation in non-reconstructable distal vascular pathology of the extremities.
我们研究了大鼠下肢模拟缺血后两种间接血运重建变体（单独移植自体骨髓单个核细胞或联合激光隧道技术）的血管生成作用。多普勒超声检查和免疫荧光研究表明，自体骨髓单个核细胞分离组分联合肌肉激光隧道技术进行肌肉内植入最为有效，可推荐作为一种刺激血管生成的方法，用于治疗四肢不可重建的远端血管病变。
