Department of Nephrology, Konya Numune State Hospital, Konya, Turkey.
Diabet Med. 2012 Aug;29(8):1043-6. doi: 10.1111/j.1464-5491.2012.03593.x.
To evaluate the prevalence of increased renal resistive index and related factors among patients with Type 2 diabetes with different levels of creatinine clearance and urinary albumin excretion.
Laboratory analyses, including calculation of 24-h urinary albumin excretion and 24-h creatinine clearance, and renal doppler ultrasonography to measure renal resistive index, were carried out for patients newly diagnosed with Type 2 diabetes mellitus.
Participants were classified into four groups according to 24-h creatinine clearance and 24-h urinary albumin excretion levels. Group 1 was composed of 73 patients (54.1%) with normal 24-h creatinine clearance and 24-h urinary albumin excretion. Group 2 was composed of 34 (25.2%) patients with normal 24-h creatinine clearance and increased 24-h urinary albumin excretion. Group 3 was composed of 14 (10.4%) patients with decreased 24-h creatinine clearance and normal 24-h urinary albumin excretion. Group 4 was composed of 14 (10.4%) patients with both decreased 24-h creatinine clearance and increased 24-h urinary albumin excretion . In total, 41 patients (30.4%) had increased renal resistive index levels. Comparison of the four groups with respect to increased renal resistive index revealed: among group 1 patients, 10 (13.7%) had increased renal resistive index levels; among group 2 patients, 14 (41.2%) had increased renal resistive index levels; among group 3 patients, eight (57.1%) had increased renal resistive index levels; among group 4 patients, nine (64.3%) had increased renal resistive index levels (P<0.0001 for trend). In multivariate regression, 24-h creatinine clearance (P<0.0001), but not 24-h urinary albumin excretion, was related to increased renal resistive index levels.
Renal resistive index levels were highest in patients with Type 2 diabetes with both decreased 24-h creatinine clearance and increased 24-h urinary albumin excretion, whereas they were lowest in patients with normal creatinine clearance and normal urinary albumin excretion.
评估不同肌酐清除率和尿白蛋白排泄率水平的 2 型糖尿病患者肾阻力指数升高的患病率及相关因素。
对新诊断为 2 型糖尿病的患者进行实验室分析，包括计算 24 小时尿白蛋白排泄量和 24 小时肌酐清除率，并进行肾脏多普勒超声检查以测量肾阻力指数。
根据 24 小时肌酐清除率和 24 小时尿白蛋白排泄水平，将参与者分为四组。第 1 组由 73 名（54.1%）肌酐清除率和 24 小时尿白蛋白排泄正常的患者组成。第 2 组由 34 名（25.2%）肌酐清除率正常但 24 小时尿白蛋白排泄增加的患者组成。第 3 组由 14 名（10.4%）肌酐清除率下降但 24 小时尿白蛋白排泄正常的患者组成。第 4 组由 14 名（10.4%）肌酐清除率和 24 小时尿白蛋白排泄均下降的患者组成。共有 41 名（30.4%）患者肾阻力指数升高。对四组肾阻力指数升高情况进行比较：第 1 组患者中有 10 名（13.7%）肾阻力指数升高；第 2 组患者中有 14 名（41.2%）肾阻力指数升高；第 3 组患者中有 8 名（57.1%）肾阻力指数升高；第 4 组患者中有 9 名（64.3%）肾阻力指数升高（趋势 P<0.0001）。多因素回归分析显示，24 小时肌酐清除率（P<0.0001），而不是 24 小时尿白蛋白排泄量与肾阻力指数升高相关。
24 小时肌酐清除率和 24 小时尿白蛋白排泄均下降的 2 型糖尿病患者肾阻力指数最高，而肌酐清除率正常且尿白蛋白排泄正常的患者肾阻力指数最低。
