转录增强子在发育和疾病中的作用。
Transcriptional enhancers in development and disease.
机构信息
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
出版信息
Genome Biol. 2012 Jan 23;13(1):238. doi: 10.1186/gb-2012-13-1-238.
Abstract
Distal transcription enhancers are cis-regulatory elements that promote gene expression, enabling spatiotemporal control of genetic programs such as those required in metazoan developmental processes. Because of their importance, their disruption can lead to disease.
摘要
远端转录增强子是顺式调控元件，可促进基因表达，从而实现基因表达的时空调控，例如在后生动物发育过程中所需的基因表达调控。由于它们的重要性，它们的破坏可能导致疾病。
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