Groĭsman S D, Fisher A A, Gel'vikh V I, Shvydchenko S I, Shevchenko O A, Kazakova S V
Fiziol Zh (1978). 1990 Jul-Aug;36(4):51-5.
It is established that clofelin suppresses the human and dog insulin gastric secretion as well as human basal and histamine secretion. Clofelin has no effect on the secretory function of the dog stomach, stimulated by pentagastrin, carbachol histamine. It is supposed that clofelin-induced suppression of the human histamine gastric secretion takes place due to the inhibition of basal secretory component being a part of the common secretory effect on histamine. Clofelin may be promising drug in the treatment of patients with hypertension and duodenum ulcer.
已证实氯苯乙胍可抑制人及犬的胰岛素性胃分泌以及人的基础分泌和组胺分泌。氯苯乙胍对由五肽胃泌素、卡巴胆碱、组胺刺激引起的犬胃分泌功能无影响。据推测，氯苯乙胍对人组胺性胃分泌的抑制作用是由于其抑制了作为对组胺共同分泌作用一部分的基础分泌成分。氯苯乙胍可能是治疗高血压和十二指肠溃疡患者的有前景的药物。
