可乐定增强清醒犬胃泌素诱导的胃酸分泌。
Enhancement of pentagastrin-induced gastric acid secretion by clonidine in the conscious dog.
作者信息
Curwain B P, Endersby K
出版信息
Br J Pharmacol. 1974 Mar;50(3):431-4. doi: 10.1111/j.1476-5381.1974.tb09621.x.
Abstract
The effect of intravenous clonidine on pentagastrin-induced gastric acid secretion has been studied in conscious dogs with Heidenhain pouches. Dose-dependent enhancement of secretion was found in response to clonidine (5-20 mu/kg). Clonidine (20 mug/kg) increased the maximal secretory rate to pentagastrin to a value not significantly different from the maximal response to histamine.
摘要
已在具有海登海因小胃的清醒犬中研究了静脉注射可乐定对五肽胃泌素诱导的胃酸分泌的影响。发现可乐定（5 - 20微克/千克）可引起剂量依赖性的分泌增强。可乐定（20微克/千克）使对五肽胃泌素的最大分泌率增加至与对组胺的最大反应值无显著差异的水平。
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本文引用的文献
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[Pharmacological effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, a new, antihypertensive substance].新型抗高血压物质2-（2,6-二氯苯基氨基）-2-咪唑啉盐酸盐的药理作用
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Acid response to gastrin and related peptides.
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The influence of 2-(2,6-dichlorphenylamino)-2-imidazoline hydrochloride (clonidine) and some related compounds on gastric secretion in the anaesthetized rat.2-（2,6-二氯苯基氨基）-2-咪唑啉盐酸盐（可乐定）及一些相关化合物对麻醉大鼠胃液分泌的影响。
Eur J Pharmacol. 1970;10(3):369-77. doi: 10.1016/0014-2999(70)90209-8.
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Effects of clonidine and guanethidine on peripheral sympathetic nerve function in the pithed rat.可乐定和胍乙啶对脊髓横断大鼠外周交感神经功能的影响。
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