Department of Ophthalmology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
Graefes Arch Clin Exp Ophthalmol. 2012 Jul;250(7):989-97. doi: 10.1007/s00417-011-1921-4. Epub 2012 Jan 22.
To determine the factors significantly associated with an enlargement of the area of a chorioretinal atrophy (ChRA) after intravitreal bevacizumab (IVB) to treat myopic choroidal neovascularization (mCNV).
The medical charts of 27 eyes with a mCNV that had received IVB were reviewed. The ophthalmic examinations included measurements of the best-corrected visual acuity, visual fields with the Humphrey 10-2 Field Analyzer, fluorescein angiography, and indocyanine green angiography. The area of the mCNV and the chorioretinal atrophy (ChRA) were measured on the FA images.
Eyes with an enlargement of the ChRA had significantly larger mCNVs at the baseline, a greater reduction in the size of the mCNV, a higher incidence of subretinal hemorrhage, longer duration of follow-up, received more injections of IVB, and had a greater decrease of retinal sensitivity (P ≤ 0.041). Multiple regression analyses showed that the factors most significantly associated with an enlargement of the ChRA were the CNV size at baseline, the number of IVB injections, and the duration of the follow-up period (P < 0.0001).
Our findings showed that eyes with a larger CNV at the baseline and longer follow-up period had a greater risk of developing a ChRA like non-treatment, even if IVB treatment was performed for mCNV.
确定与接受玻璃体内贝伐单抗（IVB）治疗近视脉络膜新生血管（mCNV）后脉络膜视网膜萎缩（ChRA）面积增大相关的显著因素。
回顾了 27 只接受 IVB 治疗的 mCNV 眼的病历。眼科检查包括最佳矫正视力、Humphrey 10-2 视野分析仪的视野测量、荧光素血管造影和吲哚青绿血管造影。mCNV 和脉络膜视网膜萎缩（ChRA）的面积在 FA 图像上进行测量。
ChRA 增大的眼在基线时有更大的 mCNV，mCNV 大小的减少更大，视网膜下出血的发生率更高，随访时间更长，接受了更多次 IVB 注射，视网膜敏感性下降更大（P≤0.041）。多元回归分析显示，与 ChRA 增大最显著相关的因素是基线时的 CNV 大小、IVB 注射次数和随访时间（P<0.0001）。
我们的发现表明，基线时 CNV 较大和随访时间较长的眼即使接受了 mCNV 的 IVB 治疗，也有更大的风险发生类似非治疗的 ChRA。
