From the Keck School of Medicine at the University of Southern California, Los Angeles, California.
Obstet Gynecol. 2012 Feb;119(2 Pt 2):436-438. doi: 10.1097/AOG.0b013e31822864af.
Neuroleptic malignant syndrome (NMS) is characterized by a tetrad of mental status changes, extrapyramidal symptoms, hyperpyrexia, and autonomic instability and can develop after the use of antipsychotics.
A young, multiparous woman presented at 26 weeks of gestation with acute psychosis and was treated with haloperidol until she developed rigidity of her extremities and then was switched to risperidone. She subsequently developed mental status changes, rigidity, hyperthermia, and autonomic instability, leading to a diagnosis of NMS. Risperidone was discontinued and, owing to ongoing psychosis, olanzapine was initiated. Subsequently, her symptoms resolved.
Neuroleptic malignant syndrome may complicate the treatment of pregnant women using antipsychotics. Clinicians should take into account the risks of untreated psychosis when discontinuing the offending agent and consider initiating alternative pharmacotherapy.
神经阻滞剂恶性综合征（NMS）的特征为精神状态改变、锥体外系症状、高热和自主神经不稳定的四联征，可在使用抗精神病药物后发生。
一位年轻的多产妇，在 26 孕周时出现急性精神病，并接受氟哌啶醇治疗，直到她出现四肢僵硬，然后换用利培酮。随后，她出现精神状态改变、僵硬、高热和自主神经不稳定，导致 NMS 的诊断。利培酮被停用，由于持续存在的精神病，给予奥氮平。随后，她的症状得到缓解。
神经阻滞剂恶性综合征可能使使用抗精神病药物治疗的孕妇复杂化。当停用有问题的药物时，临床医生应考虑到未治疗的精神病的风险，并考虑开始替代药物治疗。
