手术联合咪喹莫特局部治疗免疫抑制女性多灶性鲍恩病。
Treatment of multifocal Bowen's disease in immunocompromised women with surgery and topical imiquimod.
机构信息
From the Hematology Branch, National Heart, Lung, and Blood Institute, the Medical Genetics Branch, National Human Genome Research Institute, the Intramural Office of Rare Diseases, Office of the Director, and the Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
出版信息
Obstet Gynecol. 2012 Feb;119(2 Pt 2):442-444. doi: 10.1097/AOG.0b013e318236f1a0.
BACKGROUND
In human immunodeficiency virus (HIV)-infected women, Bowen's disease may be difficult to treat successfully with surgery alone. Imiquimod cream, effective in treating Bowen's disease in healthy women, may be a useful postsurgical treatment in immunocompromised women.
CASES
Two HIV-infected women had both Bowen's disease and severe cervical dysplasia. In both cases, Bowen's disease, but not cervical dysplasia, recurred after surgical treatment. When treated with topical 5% imiquimod cream twice weekly for 4 months, 70-80% reduction in lesions were observed in both patients. Follow-up biopsies of remaining lesions were vulvar intraepithelial neoplasia 1.
CONCLUSION
Imiquimod cream, in combination with surgical treatment, may be an appropriate strategy for treatment of Bowen's disease in HIV-infected and other immunocompromised women.
背景
在人类免疫缺陷病毒（HIV）感染的妇女中，单纯手术可能难以成功治疗鲍文病。咪喹莫特乳膏在治疗健康女性的鲍文病方面有效，可能是免疫功能低下女性术后的一种有用治疗方法。
病例
两名 HIV 感染的妇女均患有鲍文病和严重的宫颈上皮内瘤变。在这两种情况下，手术后，鲍文病而非宫颈上皮内瘤变复发。当用 5%咪喹莫特乳膏每周两次局部治疗 4 个月时，两名患者的病变均有 70-80%的减少。对残留病变的随访活检为外阴上皮内瘤变 1 级。
结论
咪喹莫特乳膏联合手术治疗可能是治疗 HIV 感染和其他免疫功能低下女性鲍文病的一种合适策略。
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