Department of Physiology, University College of Science and Technology, University of Calcutta, 92 A. P. C. Road, Kolkata, 700 009, West Bengal, India.
Eur J Appl Physiol. 2012 Sep;112(9):3397-407. doi: 10.1007/s00421-012-2317-9. Epub 2012 Jan 21.
Some cell-mediated immune responses are altered in hypobaric hypoxic (HH) condition in rats. Prostaglandins (PGs) are increased in hypobaric hypoxia and non-steroidal anti-inflammatory drugs are used to facilitate acclimatization in high altitude by inhibiting PGs. The present study explores the role of PGs in hypobaric hypoxia-induced immune responses by inhibiting its synthesis with different doses of naproxen. The rats were exposed to HH condition at 18,000 ft in a simulated chamber for 8 h/day for 6 days. The phagocytic activity of circulating blood WBC, measured by fluorescein isothiocyanate-tagged bacterial cell, was increased in HH and this change was blocked after administration of naproxen. There was reduction of natural killer cell cytotoxicity of splenic mononuclear cell and delayed type of hypersensitivity responses to bovine serum albumin in rats exposed to HH condition but these immune responses were blocked after administration of naproxen in HH condition. The leukocytes adhesive inhibition index was not altered in HH condition and after administration of naproxen in HH condition. The serum corticosterone (CORT) concentration was increased in rats exposed to HH condition and this elevated CORT concentration was blocked after administration of naproxen in HH condition. The observed HH-induced immune changes are inhibited by naproxen in a dose-dependent manner. The study indicates that hypobaric hypoxia-induced immune changes are mediated by PGs.
一些细胞介导的免疫反应在低气压低氧（HH）条件下会发生改变。在低气压缺氧条件下，前列腺素（PGs）会增加，非甾体抗炎药被用于通过抑制 PGs 来促进在高海拔地区的适应。本研究通过使用不同剂量的萘普生抑制 PGs 的合成，来探讨 PGs 在低气压缺氧诱导的免疫反应中的作用。将大鼠暴露在模拟室的 18000 英尺高度的 HH 条件下，每天 8 小时，持续 6 天。用荧光素异硫氰酸酯标记的细菌细胞测量循环血液白细胞的吞噬活性，在 HH 条件下增加，而这种变化在萘普生给药后被阻断。暴露于 HH 条件下的大鼠脾单核细胞自然杀伤细胞细胞毒性和牛血清白蛋白迟发型超敏反应减少，但这些免疫反应在 HH 条件下给予萘普生后被阻断。HH 条件下白细胞黏附抑制指数没有改变，HH 条件下给予萘普生后白细胞黏附抑制指数也没有改变。暴露于 HH 条件下的大鼠血清皮质酮（CORT）浓度升高，而这种升高的 CORT 浓度在 HH 条件下给予萘普生后被阻断。萘普生以剂量依赖的方式抑制观察到的 HH 诱导的免疫变化。该研究表明，低气压缺氧诱导的免疫变化是由 PGs 介导的。
