Saha R C, Biswas H M
Department of Physiology, University College of Science and Technology, Calcutta, India.
Int J Biometeorol. 1990 Aug;34(2):90-2. doi: 10.1007/BF01093453.
Rats were exposed intermittently for 8 h per day over 6 days at simulated high altitude of 20,000 feet. One group of altitude-exposed animals was treated with naproxen, a prostaglandin inhibiting drug. Significant reduction in body weight gain was observed in both altitude-exposed and drug-treated altitude-exposed animals compared to the control group. Right and left ventricular weights and weights of the adrenal glands were increased significantly in altitude-exposed and altitude-exposed drug-treated animals. The weight of the spleen was increased significantly in altitude-exposed animals whereas no such increase of splenic weight was observed in drug-treated altitude-exposed group of animals. On the other hand, the weight of the liver was decreased significantly in both cases. In drug-treated altitude-exposed animals, the unaltered splenic weight was thought to be due to inhibition of the erythropoietic activity.
将大鼠每天间歇性暴露于20000英尺模拟高海拔环境中，持续6天，每天暴露8小时。一组暴露于高海拔环境的动物用萘普生（一种前列腺素抑制药物）进行治疗。与对照组相比，暴露于高海拔环境的动物和经药物治疗的暴露于高海拔环境的动物体重增加均显著减少。暴露于高海拔环境的动物和经药物治疗的暴露于高海拔环境的动物的左右心室重量及肾上腺重量均显著增加。暴露于高海拔环境的动物脾脏重量显著增加，而在经药物治疗的暴露于高海拔环境的动物组中未观察到脾脏重量的这种增加。另一方面，在两种情况下肝脏重量均显著降低。在经药物治疗的暴露于高海拔环境的动物中，脾脏重量未改变被认为是由于红细胞生成活性受到抑制。
