Gasser P, Flammer J
Department of Internal Medicine, St Claraspital, Basel, Switzerland.
J Int Med Res. 1990 Jul-Aug;18(4):334-9. doi: 10.1177/030006059001800411.
It is assumed that the ocular circulation may be involved in the vasospastic syndrome and patients with vasospasm have visual field defects that are neither ophthalmologically nor neurologically explainable. A retrospective study showed that 20 mg sustained-release nifedipine treatment given orally may be helpful in these cases. There was a marked short-term effect in cases with proven peripheral vasospasms but not in similar cases without such vasospasms. The study also showed that the effect could last for up to 12 months when 20 mg nifedipine was given twice daily but the long-term effect was slightly less than the short-term effect. A number of patients had to discontinue nifedipine treatment due to side-effects.
一般认为眼循环可能与血管痉挛综合征有关，血管痉挛患者存在视野缺损，从眼科或神经科角度均无法解释。一项回顾性研究表明，口服20毫克硝苯地平缓释片治疗这些病例可能有效。在已证实有外周血管痉挛的病例中，有明显的短期效果，但在无此类血管痉挛的类似病例中则没有。该研究还表明，每日两次服用20毫克硝苯地平，效果可持续长达12个月，但长期效果略逊于短期效果。一些患者因副作用不得不停止硝苯地平治疗。
